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In Reply: We agree with Dr Khoury and colleagues. Human genomics is an excellent example of the need to improve the research roadmap and strengthen practice-based research and phase 3 (T3) translation. The best discoveries in human genomics mean little if they cannot be effectively and efficiently delivered to the patients who could benefit. Projects that might connect practice-based researchers with genomics researchers include identifying cancer links between phenotype and genotype and identifying genetic markers for predicting medication response. Identifying the best antihypertensive medication based on genetic disposition may help customize and improve hypertension management.

Moving new discoveries from the laboratory into routine clinical care is a much more complex challenge than has generally been appreciated. It is certainly larger than can be solved at current funding levels available for practice- and community-based research and phase 3 translation. The number of underused discoveries will continue to back up along the . . . [Full Text of this Article]

John M. Westfall, MD, MPH
jack.westfall@uchsc.edu
Department of Family Medicine
University of Colorado at Denver and Health Sciences Center

James Mold, MD, MPH
University of Oklahoma Health Sciences Center
Oklahoma City

Lyle Fagnan, MD
Oregon Health and Science University
Portland

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