 |
|
Folate and Cancer—Timing Is Everything
Cornelia M. Ulrich, MS, PhD;
John D. Potter, MD, PhD
JAMA. 2007;297:2408-2409.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
A large number of epidemiological studies have shown that a higher intake of folate, as well as higher intakes of vegetables and fruit, is associated with a decreased risk of colorectal polyps and cancer.1 These results have been corroborated by animal experiments,2 and biological mechanisms underlying these associations have been proposed3: folate functions as a source of carbon moieties in the synthesis of nucleotides that are essential for DNA replication and repair. Folate deficiency leads to mutations and chromosomal damage—effects that are also central to the efficacy of antifolate chemotherapeutic agents (eg, methotrexate). In addition, folate status is important for the provision of S-adenosylmethionine, the universal methyl donor, involved in normal and pathological methylation of DNA. Disturbances in DNA methylation are relevant in carcinogenesis4; however, the role of folate in these epigenetic changes is not yet understood.
. . . [Full Text of this Article]
Author Affiliations: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Wash.
RELATED ARTICLE
Folic Acid for the Prevention of Colorectal Adenomas: A Randomized Clinical Trial
Bernard F. Cole, John A. Baron, Robert S. Sandler, Robert W. Haile, Dennis J. Ahnen, Robert S. Bresalier, Gail McKeown-Eyssen, Robert W. Summers, Richard I. Rothstein, Carol A. Burke, Dale C. Snover, Timothy R. Church, John I. Allen, Douglas J. Robertson, Gerald J. Beck, John H. Bond, Tim Byers, Jack S. Mandel, Leila A. Mott, Loretta H. Pearson, Elizabeth L. Barry, Judy R. Rees, Norman Marcon, Fred Saibil, Per Magne Ueland, E. Robert Greenberg, and for the Polyp Prevention Study Group
JAMA. 2007;297(21):2351-2359.
ABSTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial
Hao et al.
Am. J. Clin. Nutr. 2008;88:448-457.
ABSTRACT
| FULL TEXT
B-Vitamin Intake, One-Carbon Metabolism, and Survival in a Population-Based Study of Women with Breast Cancer
Xu et al.
Cancer Epidemiol. Biomarkers Prev. 2008;17:2109-2116.
ABSTRACT
| FULL TEXT
Mathematical Modeling of Folate Metabolism: Predicted Effects of Genetic Polymorphisms on Mechanisms and Biomarkers Relevant to Carcinogenesis
Ulrich et al.
Cancer Epidemiol. Biomarkers Prev. 2008;17:1822-1831.
ABSTRACT
| FULL TEXT
Prediagnostic Plasma Folate and the Risk of Death in Patients With Colorectal Cancer
Wolpin et al.
JCO 2008;26:3222-3228.
ABSTRACT
| FULL TEXT
Shedding Light on Colorectal Cancer Prognosis: Vitamin D and Beyond
Ulrich and Holmes
JCO 2008;26:2937-2939.
FULL TEXT
Does Folic Acid Supplementation Prevent or Promote Colorectal Cancer? Results from Model-Based Predictions
Luebeck et al.
Cancer Epidemiol. Biomarkers Prev. 2008;17:1360-1367.
ABSTRACT
| FULL TEXT
A Prospective Study of Multivitamin Supplement Use and Risk of Breast Cancer
Ishitani et al.
Am J Epidemiol 2008;167:1197-1206.
ABSTRACT
| FULL TEXT
Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
Lin et al.
Am. J. Clin. Nutr. 2008;87:734-743.
ABSTRACT
| FULL TEXT
Vitamin and Mineral Supplement Use Among US Adults After Cancer Diagnosis: A Systematic Review
Velicer and Ulrich
JCO 2008;26:665-673.
ABSTRACT
| FULL TEXT
Circulating Concentrations of Folate and Vitamin B12 in Relation to Prostate Cancer Risk: Results from the European Prospective Investigation into Cancer and Nutrition Study
Johansson et al.
Cancer Epidemiol. Biomarkers Prev. 2008;17:279-285.
ABSTRACT
| FULL TEXT
One-Carbon Metabolism, Colorectal Carcinogenesis, Chemoprevention with Caution
Ziegler and Lim
JNCI J Natl Cancer Inst 2007;99:1214-1215.
FULL TEXT
Folate and cancer prevention: a closer look at a complex picture
Ulrich
Am. J. Clin. Nutr. 2007;86:271-273.
FULL TEXT
Folic Acid to Prevent Recurrence of Colorectal Adenomas?
JWatch Gastroenterology 2007;2007:4-4.
FULL TEXT
Folic Acid and the Risk for Recurrent Colorectal Adenomas
JWatch General 2007;2007:1-1.
FULL TEXT
|
