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Childhood Cancer Survivors, Late Effects, and a New Model for Understanding Survivorship
Kevin C. Oeffinger, MD;
Leslie L. Robison, PhD
JAMA. 2007;297:2762-2764.
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In 1950, at a time when cancer remission was measured in days, Farber stated that "The use of chemotherapeutic agents now available . . . should do much to reduce the number of instances of ‘incurable cancer’ in infants and children."1 Today, in 2007, approximately 80% of children with cancer are cured.2
However, it gradually was realized that this cure had a cost; ie, the curative therapy could damage a child's developing organ systems. Some problems, such as cognitive deficits following cranial radiotherapy, were apparent soon after completion of therapy. However, many sequelae were not recognized until survivors were a decade or more beyond their cancer. In 1974, Meadows and D’Angio described different methods and approaches to "detect the late effects of cancer therapy"3; thus began the expansion of the concept of cure to include long-term outcomes.
In this issue of JAMA, Geenen and . . . [Full Text of this Article]
Author Affiliations: Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY (Dr Oeffinger); Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tenn (Dr Robison).
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Medical Assessment of Adverse Health Outcomes in Long-term Survivors of Childhood Cancer
Maud M. Geenen, Mathilde C. Cardous-Ubbink, Leontien C. M. Kremer, Cor van den Bos, Helena J. H. van der Pal, Richard C. Heinen, Monique W. M. Jaspers, Caro C. E. Koning, Foppe Oldenburger, Nelia E. Langeveld, Augustinus A. M. Hart, Piet J. M. Bakker, Huib N. Caron, and Flora E. van Leeuwen
JAMA. 2007;297(24):2705-2715.
ABSTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Clinical Events in Adult Survivors of Childhood Cancer
JWatch General 2007;2007:5-5.
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