This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (8)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in JAMA  Social Bookmarking   What's this?

Kevin C. Oeffinger, MD; Leslie L. Robison, PhD

JAMA. 2007;297:2762-2764.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In 1950, at a time when cancer remission was measured in days, Farber stated that "The use of chemotherapeutic agents now available . . . should do much to reduce the number of instances of ‘incurable cancer’ in infants and children."¹ Today, in 2007, approximately 80% of children with cancer are cured.²

However, it gradually was realized that this cure had a cost; ie, the curative therapy could damage a child's developing organ systems. Some problems, such as cognitive deficits following cranial radiotherapy, were apparent soon after completion of therapy. However, many sequelae were not recognized until survivors were a decade or more beyond their cancer. In 1974, Meadows and D’Angio described different methods and approaches to "detect the late effects of cancer therapy"³; thus began the expansion of the concept of cure to include long-term outcomes.

In this issue of JAMA, Geenen and . . . [Full Text of this Article]

Author Affiliations: Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY (Dr Oeffinger); Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tenn (Dr Robison).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Medical Assessment of Adverse Health Outcomes in Long-term Survivors of Childhood Cancer
Maud M. Geenen, Mathilde C. Cardous-Ubbink, Leontien C. M. Kremer, Cor van den Bos, Helena J. H. van der Pal, Richard C. Heinen, Monique W. M. Jaspers, Caro C. E. Koning, Foppe Oldenburger, Nelia E. Langeveld, Augustinus A. M. Hart, Piet J. M. Bakker, Huib N. Caron, and Flora E. van Leeuwen
JAMA. 2007;297(24):2705-2715.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Long-term Outcomes in Survivors of Neuroblastoma: A Report From the Childhood Cancer Survivor Study
Laverdiere et al.
JNCI J Natl Cancer Inst 2009;101:1131-1140.
ABSTRACT | FULL TEXT  

Late Effects in Long-Term Survivors After Treatment for Childhood Acute Leukemia
Haddy et al.
CLIN PEDIATR 2009;48:601-608.
ABSTRACT  

Health Behaviors, Medical Care, and Interventions to Promote Healthy Living in the Childhood Cancer Survivor Study Cohort
Nathan et al.
JCO 2009;27:2363-2373.
ABSTRACT | FULL TEXT  

Long-Term Survivors of Childhood Cancers in the United States
Mariotto et al.
Cancer Epidemiol. Biomarkers Prev. 2009;18:1033-1040.
ABSTRACT | FULL TEXT  

Breast Cancer Surveillance Practices Among Women Previously Treated With Chest Radiation for a Childhood Cancer
Oeffinger et al.
JAMA 2009;301:404-414.
ABSTRACT | FULL TEXT  

Medical Care in Long-Term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study
Nathan et al.
JCO 2008;26:4401-4409.
ABSTRACT | FULL TEXT  

Clinical Events in Adult Survivors of Childhood Cancer
JWatch General 2007;2007:5-5.
FULL TEXT