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Genes Involved in the Pathogenesis of Primary Open-Angle Glaucoma
In Search of the Holy Grail
Commentary by Louis R. Pasquale, MD
JAMA. 2007;297:306-307.
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Archives of Ophthalmology
Identification of Novel Genetic Loci for Intraocular Pressure: A Genomewide Scan of the Beaver Dam Eye Study
Priya Duggal, MD, MPH; Alison P. Klein, PhD; Kristine E. Lee, MS; Ronald Klein, MD, MPH; Barbara E. K. Klein, MD, MPH; Joan E. Bailey-Wilson, PhD
Objective: To identify genetic loci that control intraocular pressure (IOP).
Methods: We performed a genomewide scan of IOP, using 486 pedigrees ascertained through a population-based cohort, the Beaver Dam Eye Study. Linkage analysis was performed using the modified Haseman-Elston regression models and variance components linkage analysis.
Results: Seven regions of interest were identified on chromosomes 2, 5, 6, 7, 12, 15, and 19. The novel linkage region on chromosome 19p had an empirical multipoint P value of 6.1 x 10–5. Two of the regions (2 and 19) were especially interesting since each has been identified as a . . . [Full Text of this Article]
Author Affiliations: Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Mass.
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Identification of Novel Genetic Loci for Intraocular Pressure: A Genomewide Scan of the Beaver Dam Eye Study
Priya Duggal, Alison P. Klein, Kristine E. Lee, Ronald Klein, Barbara E. K. Klein, and Joan E. Bailey-Wilson
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