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To the Editor: The study of green tea consumption and mortality by Dr Kuriyama and colleagues¹ concluded that green tea consumption is associated with reduced mortality due to all causes and due to cardiovascular disease but not with reduced mortality due to cancer. I believe that these conclusions can only be made for consumption of 100 to 500 mL/d of the green teas purchased in northeastern Japan.

Pharmacodynamic data from the National Cancer Institute indicate that for a 70-kg person, consumption of 800 mL (4 cups) of green tea that contains 710 µg/mL of (–)–epigallocatechin gallate would be required to be comparable with the lowest effective anticancer dose in animal model studies.² There is evidence of green tea as a cancer preventive for humans in other parts of Japan where quality green teas, "typical" as defined by the National Cancer Institute, are traditionally consumed.^3-4 Because amount of tea consumption and . . . [Full Text of this Article]

Sin Hang Lee, MD
sinhang.lee@milfordhospital.org
Department of Pathology
Milford Hospital
Milford, Conn

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Green Tea Consumption and Mortality in Japan—Reply
Shinichi Kuriyama, Yoshikazu Nishino, Yoshitaka Tsubono, and Ichiro Tsuji
JAMA. 2007;297(4):360-361.
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Green Tea Consumption and Mortality Due to Cardiovascular Disease, Cancer, and All Causes in Japan: The Ohsaki Study
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