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In Reply: Our study found a statistically nonsignificant increase in the risk of cancer death among participants who consumed 5 or more cups of green tea per day compared with participants who drank less than 1 cup per day, with a hazard ratio of 1.11 (95% confidence interval, 0.90-1.36) in men and 1.07 (95% confidence interval, 0.80-1.44) in women. We were unable to divide this highest category of consumption into subcategories, such as 10 or more cups/d and 5 to 9 cups/d, because these subcategories were not included on the questionnaire completed by the participants.

Dr Lee argues that our lack of inverse results might be partly explained by the categories we used, citing 3 articles^1-3 as evidence that the risk of cancer decreases only with very high consumption of green tea. However, one of these articles¹ reports the results of animal models, and such findings are not always replicated . . . [Full Text of this Article]

Shinichi Kuriyama, MD, PhD
kuriyama-thk@umin.ac.jp
Division of Epidemiology
Department of Public Health and Forensic Medicine
Tohoku University Graduate School of Medicine
Sendai, Japan

Yoshikazu Nishino, MD, PhD
Division of Epidemiology
Miyagi Cancer Center Research Institute
Natori, Japan

Yoshitaka Tsubono, MD, PhD
Division of Health Policy
Tohoku University School of Public Policy
Sendai, Japan

Ichiro Tsuji, MD, PhD
Division of Epidemiology
Department of Public Health and Forensic Medicine
Tohoku University Graduate School of Medicine
Sendai, Japan

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