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Rapid Dissection of the Genetic Risk of Age-Related Macular Degeneration
Achieving the Promise of the Genomic Era
Commentary by Jonathan L. Haines, PhD;
Margaret A. Pericak-Vance, PhD
JAMA. 2007;297:401-402.
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ARCHIVES OF OPHTHALMOLOGY
A Prospective Study of 2 Major Age-Related Macular Degeneration Susceptibility Alleles and Interactions With Modifiable Risk Factors
Debra A. Schaumberg, ScD, OD, MPH; Susan E. Hankinson, ScD; Qun Guo, MSc; Eric Rimm, ScD; David J. Hunter, MBBS, ScD
Objectives To delineate the magnitude of susceptibility to age-related macular degeneration (AMD) due to common variants in the gene for complement factor H (CFH) and the predicted gene LOC387715 and to determine whether these variants interact with modifiable risk factors.
Methods We compared cases who developed AMD (n = 457) with 1071 age- and sex-matched control subjects in a prospective nested case-control study within the Nurses' Health Study and the Health Professionals Follow-up Study. We determined the incidence rate ratios and 95% confidence intervals (CIs) for AMD for each genotype and examined the interactions with modifiable risk factors.
Results . . . [Full Text of this Article]
Author Affiliations: Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tenn (Dr Haines) and Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Fla (Dr Pericak-Vance).
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A Prospective Study of 2 Major Age-Related Macular Degeneration Susceptibility Alleles and Interactions With Modifiable Risk Factors
Debra A. Schaumberg, Susan E. Hankinson, Qun Guo, Eric Rimm, and David J. Hunter
Arch Ophthalmol. 2007;125(1):55-62.
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