This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related letters  • Similar articles in JAMA  Topic Collections  • Neurology  • Pediatrics  • Pediatrics, Other  • Radiologic Imaging  • Women's Health  • Pregnancy and Breast Feeding  • Magnetic Resonance Imaging  • Alert me on articles by topic  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In Reply: The letter by Dr Caspi and colleagues raises 3 critical points in understanding the complexity of the CP syndromes.

First, regarding practice recommendations, Ashwal et al¹ explicitly stated "In order to establish that a brain abnormality exists in children with CP that may, in turn, suggest an etiology and prognosis, neuroimaging is recommended with MRI preferred to CT (Level A)," as well as "Large prospective cohorts of children with CP should be studied to identify features based on CP subtypes that can improve specific evaluation strategies and enhance etiologic yield." Bax et al² carried out this most important task.

Second, regarding timing of MRI scans at 18 months of age, the most rapid changes in myelination occur within the first 8 postnatal months.³ With respect to central white matter, 50% of infants attain mature myelin in the precentral gyrus at 30 weeks, occipital poles at 47 weeks, posterior . . . [Full Text of this Article]

Michael E. Msall, MD
mmsall@peds.bsd.uchicago.edu
University of Chicago Comer Children's Hospital
Chicago, Ill

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

RELATED LETTERS

MRI Findings and Cerebral Palsy
Russel D. Jelsema
JAMA. 2007;297(5):465.
EXTRACT | FULL TEXT  

MRI Findings and Cerebral Palsy
Colin L. Crawford
JAMA. 2007;297(5):465.
EXTRACT | FULL TEXT  

MRI Findings and Cerebral Palsy
Opher Caspi, Burris Duncan, Tong Li Han, and Li-Ping Zou
JAMA. 2007;297(5):466.
EXTRACT | FULL TEXT  

MRI Findings and Cerebral Palsy—Reply
Martin Bax, Olof Flodmark, and Clare Tydeman
JAMA. 2007;297(5):466-467.
EXTRACT | FULL TEXT