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Joan Stephenson, PhD

JAMA. 2007;297:686.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Individuals with a particular gene variant have a substantially increased risk of cerebral infarction, the most common type of stroke, according to findings by Japanese researchers (Kubo M et al. Nat Genet. doi:10.1038/ng1945 [published online January 7, 2007]).

In a case-control study of 1112 Japanese individuals with cerebral infarction and 1112 controls, the researchers identified one gene variant, PRKCH, that was associated with a 40% increased risk of lacunar stroke. (About 20% of all strokes and 40% of cerebral infarctions are this subtype.) The researchers confirmed the association in another population of Japanese patients with cerebral infarction.

The protein encoded by the gene is one of the PKC (protein kinase C) family of enzymes; the gene variant (PKC) produces a more active form of the enzyme. The researchers found that PKC was expressed mainly in vascular endothelial cells and foamy macrophages in human atherosclerotic lesions, . . . [Full Text of this Article]

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