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Genetic Ophthalmology and the Era of Clinical Care
Commentary by Paul A. Sieving, MD, PhD;
Francis S. Collins, MD, PhD
JAMA. 2007;297:733-736.
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Genetics is rapidly entering the realm of clinical medicine. The January and February 2007 issues of the Archives of Ophthalmology, a member of the JAMA and Archives Journals family of publications, provide a view into the field of medical genetics through the remarkable recent advances in ophthalmic genetics that are beginning to drive medical vision care.1-2
Discovering Genetic Factors for Ocular Disease
Nearly 25 centuries ago Hippocrates recognized that the trait of blue eyes is inherited, and in 350 BC, Aristotle commented on the transmission of vision impairment across generations.3 Yet, as recently as 1980, only a few ocular disease genes had been identified.4 Now, little more than 2 decades later, and greatly facilitated by the databases and technologies produced by the Human Genome Project, more than 400 genes are cloned or mapped that cause or contribute to eye and vision diseases.4-5 . . . [Full Text of this Article]
Author Affiliations: National Eye Institute (Dr Sieving) and National Human Genome Research Institute (Dr Collins), National Institutes of Health, Bethesda, Md.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Genomics in the Era of Molecular Ophthalmology: Reflections on the National Ophthalmic Disease Genotyping Network (eyeGENE)
Brooks et al.
Arch Ophthalmol 2008;126:424-425.
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