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In Reply: In response to Dr Bierut and colleagues, the central motivation of our Commentary was not to curtail research funding, and we hope that a careful reading will dissuade others from this interpretation. Rather, we argued for wise use of public resources.¹ The relative or absolute amount of funding directed toward genetic studies of smoking behavior or its complications is not critical to the debate. Our goal is to encourage a thoughtful "step back" from current smoking-related genetic research to consider how such work interfaces with existing public health efforts in this arena.

We take issue with the suggestion that our call was solely for "results that have immediate clinical application." Certainly, research funders must place an appropriate priority on research likely to yield short-term benefits, and smoking-related genetic research is unlikely to meet this criterion. However, we noted other potential long-term benefits from such research: it might provide . . . [Full Text of this Article]

Chris Carlsten, MD, MPH
carlsten@u.washington.edu

Wylie Burke, MD, PhD
University of Washington
Seattle

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