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Combination of Sumatriptan and Naproxen for Migraine—Reply
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In Reply: Drs Hill and Hope indicate an apparent preference for coadministration of the separate components of sumatriptan–naproxen sodium for migraine attacks. We believe that our study provides evidence of efficacy and safety of the single fixed-dose table in replicated randomized controlled trials, whereas trials of coadministration of specific regimens of the individual components have not been replicated.
The practicalities of treatment remain at issue with migraine. Adherence to prescribing directions is often difficult during an acute migraine attack—hence, our concerns of relapse to a "step care" situation—and failure of adherence is unlikely to provide patients with the degree of efficacy reported in our study.1 The prescribing simplicity of a single sumatriptan–naproxen sodium tablet should help improve adherence.
Financial Disclosures: Dr Brandes reports having received clinical research or educational support from Merck, GlaxoSmithKline, UCB Pharma, Allergan, Johnson & Johnson, AstraZeneca, Pfizer, Bristol-Myers Squibb, Winston Laboratories, Sanofi-Aventis, Elan Pharmaceuticals, Novartis, Endo, . . . [Full Text of this Article]
Jan Lewis Brandes, MD
jbrandes@nashvilleneuroscience.com
Nashville Neuroscience Group
Nashville, Tennessee
David Kudrow, MD
California Medical Clinic for Headache
Santa Monica
Stuart R. Stark, MD
The Innovative Clinical Research Center
Alexandria, Virginia
C. Phillip O’Carroll, MD
Headache Institute
Newport Beach, California
James U. Adelman, MD
Headache Wellness Center
Greensboro, North Carolina
Francis J. O’Donnell, DO
OrthoNeuro
Columbus, Ohio
W. James Alexander, MD, MPH;
Susan E. Spruill, MS
POZEN Inc
Chapel Hill, North Carolina
Pamela S. Barrett, PharmD;
Shelly E. Lener, PharmD
GlaxoSmithKline
Research Triangle Park, North Carolina
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