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Prostate cancer (an abnormal, uncontrolled growth of cells originating in the prostate gland) is the most common cancer among American men. The October 3, 2007, issue of JAMA includes an article on the importance of grading prostate cancer and the implications regarding therapy options and possible recurrence.

DIAGNOSTIC TESTING FOR PROSTATE CANCER

Doctors and medical groups do not agree on when men should be screened (routinely tested) for prostate cancer because of controversy about the benefits versus risks of early treatment. The most often used tests include

• Digital rectal examination (DRE). A doctor feels the prostate gland by passing a gloved finger into the patient's rectum to examine the gland for hard or lumpy areas that may represent an abnormality.
  
• Prostate-specific antigen (PSA) test. A blood test is performed to measure levels of this chemical substance. A positive test result (usually considered to be more than 4 nanograms per milliliter) may be an indicator of . . . [Full Text of this Article]

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PSA Failure Following Definitive Treatment of Prostate Cancer Having Biopsy Gleason Score 7 With Tertiary Grade 5
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JAMA. 2007;298(13):1533-1538.
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