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Joan Stephenson, PhD

JAMA. 2007;298:1752.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Exposure to diesel exhaust promotes myocardial ischemia and inhibits the body's ability to dispel blood clots, a finding that might help explain why exposure to poor air quality is associated with adverse cardiovascular events, according to a study by researchers in Scotland and Sweden (Mills NL et al. N Engl J Med. 2007;357[11]:1075-1082).

The double-blind, randomized crossover study involved 20 men who had previously experienced myocardial infarction. The men were monitored via electrocardiography while they were exposed to diesel exhaust (at concentrations found in urban road traffic) or filtered air for 1 hour during brief periods of peddling an exercise bicycle and at rest.

The researchers found that the men experienced a greater increase in ischemic burden during exposure to diesel exhaust, as well as a reduced level of the clot-busting protein tissue plasminogen activator. "Our findings point to ischemic and thrombotic mechanisms that may explain . . . [Full Text of this Article]

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