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To the Editor: Dr Morgan and colleagues¹ were unable to replicate previously reported positive association findings of 84 genetic variants with ACS in a large-scale case-control study. The authors discussed a number of factors contributing to the nonreplication of results in candidate gene association studies and suggest that whole genome analyses may be a useful alternative. The ability to evaluate the entire genome for genetic association with common multifactorial diseases (such as ACS) is certainly an exciting development. However, these studies do not resolve most of the problems already present in candidate gene analyses and may lead to even more false results.

Genomewide association analyses examine the potential correlation of disease phenotypes with variations in genetic markers. More than 300 000 genetic variants may need to be genotyped to provide satisfactory coverage of the human genome in such studies.² Given that such a large number of variants needs to be examined . . . [Full Text of this Article]

William Y.S. Wang, MMBS, PhD
wwang@usyd.edu.au
University of Sydney
Sydney, Australia

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