This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related letters  • Related article  • Similar articles in JAMA  Topic Collections  • Cardiovascular Disease/ Myocardial Infarction  • Alert me on articles by topic  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In Reply: I concur with Dr Tsarpalis that the use of a formal oral triglyceride tolerance test (OTTT) is likely to be the best method for defining postprandial hypertriglyceridemia and to standardize the metabolic response to fat loading. In 1950, Moreton¹ suggested interrelationships between chylomicronemia, fat tolerance, and atherosclerosis, and proposed that an OTTT analogous to the glucose tolerance test be used for vascular risk detection.

Several protocols for OTTT have been investigated, including those that vary fat intake according to body weight (1 g dairy cream per kilogram body weight),² as well as those using a fixed combined challenge (50 g fat plus 50 g carbohydrate).³ In controlled studies of healthy individuals as well as those with metabolic syndrome or diabetes, blood levels obtained 2 to 4 hours after these standardized fat loads have proven effective for assessing postchallenge triglyceride levels.³ This was the time frame when maximal cardiovascular . . . [Full Text of this Article]

Paul M Ridker, MD
pridker@partners.org
Brigham and Women's Hospital
Boston, Massachusetts

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED LETTERS

Nonfasting Triglycerides and Cardiovascular Risk
William S. Yancy, Jr, Jeff S. Volek, and Eric C. Westman
JAMA. 2007;298(17):2004.
EXTRACT | FULL TEXT  

Nonfasting Triglycerides and Cardiovascular Risk
Konstantinos Tsarpalis
JAMA. 2007;298(17):2004-2005.
EXTRACT | FULL TEXT  

Nonfasting Triglycerides and Cardiovascular Risk—Reply
Børge G. Nordestgaard, Marianne Benn, and Anne Tybjærg-Hansen
JAMA. 2007;298(17):2005.
EXTRACT | FULL TEXT  

RELATED ARTICLE

Nonfasting Triglycerides and Risk of Myocardial Infarction, Ischemic Heart Disease, and Death in Men and Women
Børge G. Nordestgaard, Marianne Benn, Peter Schnohr, and Anne Tybjærg-Hansen
JAMA. 2007;298(3):299-308.
ABSTRACT | FULL TEXT