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Pharmacotherapy for Adolescent Smoking Cessation
Commentary by Suzanne M. Colby, PhD;
Chad J. Gwaltney, PhD
JAMA. 2007;298(18):2182-2184.
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ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
Randomized, Double-blind, Placebo-Controlled Trial of 2 Dosages of Sustained-Release Bupropion for Adolescent Smoking Cessation
Myra L. Muramoto, MD, MPH; Scott J. Leischow, PhD; Duane Sherrill, PhD; Eva Matthews, MPH; Louise J. Strayer, BSc, RN, MSc
Objective: To assess the safety and efficacy of sustained-release bupropion hydrochloride for adolescent smoking cessation.
Design: Prospective, randomized, double-blind, placebo-controlled, dose-ranging trial.
Setting: Metropolitan areas of Tucson and Phoenix, Arizona.
Participants: Adolescents (N = 312) recruited through media and various community venues from March 1, 1999, through December 31, 2002, who were aged 14 to 17 years, smoked 6 or more cigarettes per day, had an exhaled carbon monoxide level of 10 ppm or greater, had at least 2 previous quit attempts, and had no other current major psychiatric diagnosis.
Intervention: Sustained-release bupropion hydrochloride, 150 mg/d (n = 105) or 300 mg/d (n = 104), . . . [Full Text of this Article]
Author Affiliations: Center for Alcohol and Addiction Studies (Drs Colby and Gwaltney), and Departments of Psychiatry and Human Behavior (Dr Colby) and Community Health (Dr Gwaltney), Brown University, Providence, Rhode Island.
RELATED ARTICLE
Randomized, Double-blind, Placebo-Controlled Trial of 2 Dosages of Sustained-Release Bupropion for Adolescent Smoking Cessation
Myra L. Muramoto, Scott J. Leischow, Duane Sherrill, Eva Matthews, and Louise J. Strayer
Arch Pediatr Adolesc Med. 2007;161(11):1068-1074.
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