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Therapies Aim to Hold Cells in a Nondividing State

Tracy Hampton, PhD

JAMA. 2007;298(20):2357-2358.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Madrid, Spain—Malignant cancers are adept at disrupting the body's efforts to maintain order and normalcy, but research is finding that it may be possible to reinstate the defenses that tumor cells overcome. Mechanisms that slow or inhibit the progression of cancer include apoptosis (programmed cell death) and oncogene-induced senescence, a nondividing state that occurs in response to the expression of cancer-causing genes. Disrupting these processes is often necessary for rogue cancer cells to thrive, and scientists hope that keeping them in place will have therapeutic potential.

Seeking alternatives to treatments that kill cancer cells, researchers are working to develop new therapies that will keep tumor cells in an arrested state called senescence.

While apoptosis has been well-studied over the years, oncogene-induced senescence is less well-defined but is garnering increased interest among oncology researchers. Ongoing studies related to this process were discussed in October at Oncogenes and . . . [Full Text of this Article]

SENESCENCE IN BENIGN LESIONS



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