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Risk of Diabetes in Patients With Rheumatoid Arthritis Taking Hydroxychloroquine—Reply
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In Reply: Dr Di Comite and Mr Rossi suggest that cumulative prednisone dosage be determined to assess the contribution of this drug to the incidence of diabetes, indicating that (1) a lower prednisone dosage would likely be required for those taking hydroxychloroquine and (2) those patients who had never taken hydroxychloroquine might have had more exposure to prednisone based on their greater age, rheumatoid arthritis duration, and disability. In our time-to-event analyses, we adjusted for cumulative duration of prednisone use; our time-varying Cox proportional hazards analyses included adjustment for prednisone use (yes/no) in each cycle.
The proportion of patients who had taken prednisone was higher in those who had ever taken hydroxychloroquine than among those who had never taken hydroxychloroquine. Among patients treated with prednisone, the mean prednisone dosage for patients who had ever taken hydroxychloroquine was 6.5 (median, 5.0) mg/d; it was 6.7 (median, 5.0) mg/d for those who . . . [Full Text of this Article]
Mary Chester M. Wasko, MD, MSc
wasko@pitt.edu
Division of Rheumatology and Clinical Immunology
University of Pittsburgh
Pittsburgh, Pennsylvania
Helen B. Hubert, MPH, PhD;
Vijaya Bharathi Lingala, PhD
Stanford University Medical Center
Palo Alto, California
Jennifer Rae Elliott, MD
Division of Rheumatology and Clinical Immunology
University of Pittsburgh
Michael E. Luggen, MD
Division of Immunology
University of Cincinnati
Cincinnati, Ohio
James F. Fries, MD
Stanford University Medical Center
Michael M. Ward, MD, MPH
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Bethesda, Maryland
RELATED LETTER
Risk of Diabetes in Patients With Rheumatoid Arthritis Taking Hydroxychloroquine
Gabriele Di Comite and Carlo M. Rossi
JAMA. 2007;298(20):2368-2369.
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