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Tracy Hampton, PhD

JAMA. 2007;298(21):2474.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Studies using transparent zebrafish to investigate how human cancer cells invade tissues and interact with blood vessels have led to insights into the role of 2 proteins in the metastasis of malignant cells in inflammatory breast cancer (Stoletov K et al. Proc Natl Acad Sci U S A. doi: [published online ahead of print October 22, 2007]).

Researchers at the University of California at San Diego in La Jolla found that vascular endothelial growth factor (VEGF) and RhoC proteins work together to allow breast cancer cells to enter blood vessels. VEGF stimulates new blood vessel formation, while RhoC is involved in cell movement or migration.

For their studies, the researchers developed an immunosuppressed zebrafish that expresses a green fluorescent marker only in its blood vessels, allowing scientists to view tumor-induced blood vessel formation, or angiogenesis. They injected these fish with inflammatory breast cancer cells that were . . . [Full Text of this Article]