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Statin Use and Sepsis in Patients With Chronic Kidney Disease—Reply
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In Reply: Drs Chenaud and Merlani speculate on a possible mechanism to explain the association of statin use with reduced rate of hospitalization for sepsis in our analysis of the CHOICE study. They point out that apo A-I has been found to have potentially desirable effects in sepsis models and that statins may increase apo A-I levels.
There certainly have been interesting reports describing associations between cholesterol levels and sepsis outcomes,1-2 as well as multiple studies of apo A-I and high-density lipoprotein cholesterol in models of sepsis.3-4 We examined apo A-I levels that were available for a subset of our cohort (n = 850).5 While the levels were slightly higher in statin users than in control patients (135 vs 132 mg/dL, respectively [to convert to mmol/L, multiply by 0.0259]), the difference was not statistically significant (P = .31). Additionally, we did not find an association of apo A-I levels with incidence of . . . [Full Text of this Article]
Rajesh Gupta, MD
Division of Cardiology
Northwestern University
Chicago, Illinois
Laura C. Plantinga, ScM
Department of Medicine
Johns Hopkins University School of Medicine
Baltimore, Maryland
Josef Coresh, MD, PhD
Department of Epidemiology
Johns Hopkins Bloomberg School of Public Health
Neil R. Powe, MD, MPH, MBA
npowe@jhmi.edu
Department of Medicine
Johns Hopkins University School of Medicine
RELATED LETTER
Statin Use and Sepsis in Patients With Chronic Kidney Disease
Catherine Chenaud and Paolo Merlani
JAMA. 2007;298(3):284.
EXTRACT
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RELATED ARTICLE
Statin Use and Hospitalization for Sepsis in Patients With Chronic Kidney Disease
Rajesh Gupta, Laura C. Plantinga, Nancy E. Fink, Michal L. Melamed, Josef Coresh, Caroline S. Fox, Nathan W. Levin, and Neil R. Powe
JAMA. 2007;297(13):1455-1464.
ABSTRACT
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