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Tracy Hampton, PhD

JAMA. 2008;299(1):28.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A previously halted gene therapy trial for the treatment of rheumatoid arthritis has been given the green light to resume.

The trial, conducted by Seattle-based Targeted Genetics Corporation, was shut down this summer after Jolee Mohr, aged 36 years, died 3 weeks after receiving a gene therapy injection to treat inflammatory arthritis. Mohr enrolled in this phase 1/2 trial of a new gene therapy, which involved injections of an adeno-associated virus vector carrying a gene coding for a protein that inhibits tumor necrosis factor (TNF-), a proinflammatory cytokine. Mohr received an initial injection in her right knee in February and a second in July.

At a September meeting of the National Institutes of Health Recombinant DNA Advisory Committee (RAC), experts determined that the patient apparently died because she had a severely compromised immune system and succumbed to a fungal infection. Mohr's liver, lungs, and other tissues were . . . [Full Text of this Article]