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Joan Stephenson, PhD

JAMA. 2008;299(11):1252.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Three independent groups of scientists from Europe and the United States have identified at least 10 previously unknown gene variants linked to prostate cancer susceptibility, according to findings reported online ahead of print on February 10 (Eeles RA et al. Nat Genet. doi:10.1038/ng.90; Thomas G et al. Nat Genet. doi:10.1038/ng.91; Gudmundsson J et al. Nat Gene doi:10.1038/ng.89).

Each of the groups conducted genome-wide association studies of thousands of individuals with and without prostate cancer. All told, 10 gene loci on chromosomes 2, 3, 6, 7, 10, and 11 and the X chromosome were found.

Although the researchers have not yet identified the specific genes flagged by these genetic markers, some of the loci contain or are near plausible candidate genes, including KLK3, the gene that encodes prostate-specific antigen; CTBP2, a gene with antiapoptotic activity that is expressed in prostate tissue; and MSMB, . . . [Full Text of this Article]