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To the Editor: Increased daily physical activity is associated with improved health,¹ but it is uncertain whether it prevents initial metabolic events that produce chronic diseases. We are aware of no evidence in healthy, young adults that reduced daily stepping within a free-living environment is associated with negative metabolic consequences. The purpose of this study was to reduce daily steps and assess metabolic changes.

Methods

Participants were recruited for 2 substudies by advertisement and received compensation. Inclusion criteria were asymptomatic nonsmokers without family history of diabetes mellitus, medication use, or physical abnormalities; exclusion criteria were walking fewer than 3500 steps per day measured over 1 week (Yamax Digi-Walker SW-200 pedometer; Great Performance Ltd, London, United Kingdom) or performing more than 2 hours of regular exercise per week. The studies were approved by the local scientific-ethical committee, and participants provided written informed consent.

Participants were instructed to reduce daily steps by taking . . . [Full Text of this Article]

Rasmus H. Olsen, MD; Rikke Krogh-Madsen, MD
krogh-madsen@inflammation-metabolism.dk
Centre of Inflammation and Metabolism

Carsten Thomsen, MD, DMSc
Department of Radiology
Rigshospitalet
University of Copenhagen
Copenhagen, Denmark

Frank W. Booth, PhD
Health Activity Center
Department of Biomedical Sciences
University of Missouri
Columbia

Bente K. Pedersen, MD, DMSc
Centre of Inflammation and Metabolism
Rigshospitalet
University of Copenhagen

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