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Crohn Disease
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Crohn disease and ulcerative colitis are chronic inflammatory bowel diseases (IBDs). Although they have similar symptoms, they are different disease processes. Ulcerative colitis affects only the colon (large intestine). Crohn disease may involve the entire gastrointestinal (GI) tract but most often occurs in the ileum (the last part of the small intestine). Irritable bowel syndrome has symptoms similar to IBD, but is not an immune disease. The inflammation seen in Crohn disease has similarities to the disease process of other immune diseases such as rheumatoid arthritis: the body's immune system reacts to antigens (proteins from the environment such as bacteria or food components that the body senses as invaders) and this causes the inflammatory process. The April 9, 2008, issue of JAMA includes an article about Crohn disease.
SIGNS AND SYMPTOMS
- Diarrhea
- Rectal bleeding
- Abdominal pain
- Weight loss
- Arthritis
- Fever
- Anemia
- Poor growth in children
DIAGNOSIS AND TESTING
With a complete medical history . . . [Full Text of this Article]
Janet M. Torpy, MD, Writer;
Cassio Lynm, MA, Illustrator;
Richard M. Glass, MD, Editor
RELATED ARTICLE
Omega-3 Free Fatty Acids for the Maintenance of Remission in Crohn Disease: The EPIC Randomized Controlled Trials
Brian G. Feagan, William J. Sandborn, Ulrich Mittmann, Simon Bar-Meir, Geert D’Haens, Marc Bradette, Albert Cohen, Chrystian Dallaire, Terry P. Ponich, John W. D. McDonald, Xavier Hébuterne, Pierre Paré, Pavel Klvana, Yaron Niv, Sandro Ardizzone, Olga Alexeeva, Alaa Rostom, Gediminas Kiudelis, Johannes Spleiss, Denise Gilgen, Margaret K. Vandervoort, Cindy J. Wong, Guang Yong Zou, Allan Donner, and Paul Rutgeerts
JAMA. 2008;299(14):1690-1697.
ABSTRACT
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