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Vitamin E Concentration and Physical Decline in Older Persons—Reply
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In Reply: In response to Dr Krul and colleagues, the concentration of vitamin E did not differ significantly between the 698 persons in our study sample (mean, 30.6 µmol/L [to convert to µg/uL, divide by 23.22]) and the 457 persons who were excluded (mean, 29.2 µmol/L; P = .15) after adjustment for age, which differed between the 2 groups. Among the subset of excluded persons who were lost to follow-up (n = 214), the mean age was 76.5 years and the mean concentration of vitamin E was 30.2 µmol/L. Although the age of these persons was significantly older than that in our study sample (P < .001), the concentration of vitamin E did not differ between the 2 groups (adjusted for age, P = .82).
We agree that persons who were lost to follow-up may have had high rates of decline in physical function. Nonetheless, a sensitivity analysis assuming that all 214 of these . . . [Full Text of this Article]
Benedetta Bartali, RD, PhD
Department of Internal Medicine
Yale University School of Medicine
New Haven, Connecticut
benedetta.bartali@yale.edu
Luigi Ferrucci, MD, PhD
Longitudinal Studies Section
Clinical Research Branch
National Institute on Aging
Bethesda, Maryland
Thomas Gill, MD
Department of Internal Medicine
Yale University School of Medicine
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ABSTRACT
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RELATED LETTER
Vitamin E Concentration and Physical Decline in Older Persons
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JAMA. 2008;299(17):2021.
EXTRACT
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