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To the Editor: In his Commentary, Dr Woolf¹ identified a critical problem in the field of translational research—lack of clarity in nomenclature. Vague language conflates very different types of research and fosters definitional creep as researchers struggle to ensure that their own work falls under this umbrella. We agree that the terms T1 and T2 lack inherent meaning and should be replaced with ones that are more descriptive.

We suggest that T1 be replaced with the term preclinical research. We define this as research designed to yield a tool or an intervention related to screening, risk assessment, prevention, diagnosis, treatment, or rehabilitation that will be suitable for clinical evaluation within 10 years. Long-term preclinical translational research would have a time frame of 5 to 10 years. Short-term preclinical translational research would be less than 5 years. Basic research that has an anticipated time frame beyond 10 years would not . . . [Full Text of this Article]

Kevin Fiscella, MD, MPH
kevin_fiscella@urmc.rochester.edu
Department of Family Medicine

Nancy M. Bennett, MD, MS
Department of Medicine

Peter G. Szilagyi, MD, MPH
Department of Pediatrics
University of Rochester School of Medicine and Dentistry
Rochester, New York

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