This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Related letters  • Similar articles in JAMA  Topic Collections  • Nutritional and Metabolic Disorders, Other  • Cardiovascular Disease/ Myocardial Infarction  • Drug Therapy, Other  • Diabetes Mellitus  • Alert me on articles by topic

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: There is experimental evidence supporting 2 arguments for the ideal timing of administration of GIK for animal model MI, neither of which is covered by the data in the OASIS-6/CREATE-ECLA study by Dr Díaz and colleagues.¹ First, GIK infused to baboons within 1 hour of coronary ligation improved the myocardial markers of necrosis and levels of high-energy phosphates.² In longer dog experiments, GIK that was beneficial was started within 30 minutes of coronary ligation.³ Second, data on rodent hearts show that insulin given at the time of perfusion lessens reperfusion-induced myocardial injury,⁴ which in humans could be one-third of the threatened cells, as judged by diminished enzyme release after reperfusion with another intervention (ischemic postconditioning).⁴

The results in the group of patients undergoing reperfusion in the ECLA center are not reported separately, despite previous positive results.⁵ Hence it is not possible to know whether reperfusion injury was . . . [Full Text of this Article]

Lionel H. Opie, MD, DPhil
lionel.opie@uct.ac.za
Hatter Institute for Cardiovascular Research
Department of Medicine
University of Cape Town Faculty of Health Sciences
Cape Town, South Africa

RELATED ARTICLE

Glucose-Insulin-Potassium Therapy in Patients With ST-Segment Elevation Myocardial Infarction
Rafael Díaz, Abhinav Goyal, Shamir R. Mehta, Rizwan Afzal, Denis Xavier, Prem Pais, Susan Chrolavicius, Jun Zhu, Khawar Kazmi, Lisheng Liu, Andrzej Budaj, Mohammad Zubaid, Alvaro Avezum, Mikhail Ruda, and Salim Yusuf
JAMA. 2007;298(20):2399-2405.
ABSTRACT | FULL TEXT  

RELATED LETTERS

Glucose-Insulin-Potassium Therapy in Patients With STEMI
Harry P. Selker, Joanne Ingwall, and Charles E. Rackley
JAMA. 2008;299(20):2385.
EXTRACT | FULL TEXT  

Glucose-Insulin-Potassium Therapy in Patients With STEMI
Rohit R. Arora and Srikanth Katragadda
JAMA. 2008;299(20):2386.
EXTRACT | FULL TEXT  

Glucose-Insulin-Potassium Therapy in Patients With STEMI
Ajay Chaudhuri, Richard Nesto, and Paresh Dandona
JAMA. 2008;299(20):2386-2387.
EXTRACT | FULL TEXT  

Glucose-Insulin-Potassium Therapy in Patients With STEMI—Reply
Abhinav Goyal, Rafael Díaz, and Shamir R. Mehta
JAMA. 2008;299(20):2387-2388.
EXTRACT | FULL TEXT