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To the Editor: Dr Schetter and colleagues¹ demonstrated that high microRNA miR-21 expression in colon adenocarcinoma tissue was associated with a low survival rate and resistance to chemotherapy. Table 2 of their article listed microRNAs with significantly higher expression in tumors, including miR-335. Recently, miR-335 was reported to be a metastasis-suppressor microRNA in breast cancer, indicating that miR-335 may prevent tumor progression.² It is possible that miR-335 has an opposite function in breast cancer vs colon cancer.³ The expression of miR-335 might be secondary during inhibition of tumor metastasis. We would be interested in the authors' interpretation of these differing findings.

Although the authors analyzed microRNA with higher expression in tumors, it would also be valuable to know whether there is an inverse association between prognostic outcomes and the microRNA with reduced expression in tumors listed in Table 2. These microRNAs also might be useful prognostic markers.

Finally, the . . . [Full Text of this Article]

Yujiro Kida, MD, PhD; Yuan-Ping Han, PhD
Keck School of Medicine
University of Southern California
Los Angeles

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