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Bridget M. Kuehn

JAMA. 2008;299(6):619-620.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Emerging evidence suggests that proteins associated with the immune system may play additional roles in normal brain development and in the healthy adult brain. Studies also suggest that perturbations of these roles may underlie some neurological diseases.

Key immune system proteins are active in the brain, as illustrated by this cross section of a mouse brain showing expression of 3 such proteins (shown in red, blue, and green). (Photo credit: Gene S. Huh, PhD, and Carla J. Shatz, PhD)

Contrary to dogma that the blood-brain barrier protects the brain from the immune system by acting as a barricade to its components, scientists have found that certain key immune system proteins are, in fact, expressed and active in healthy brains. For instance, a growing body of evidence highlighted at the annual meeting of the Society for Neuroscience in November suggests that proteins of the major histocompatibility complex class . . . [Full Text of this Article]

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