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Notice to Readers: Potential Exposure to Attenuated Vaccine Strain Brucella abortus RB51 During a Laboratory Proficiency Test—United States, 2007
JAMA. 2008;299(6):630.
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MMWR. 2007;56:1320-1321
On November 27, 2007, CDC was notified by New York State Department of Health (NYSDOH) officials of potential Brucella abortus RB51 (RB51) exposures to laboratorians at a state laboratory from an isolate used in a recent Laboratory Preparedness Survey (LPS). RB51 is an attenuated vaccine strain of B. abortus used to vaccinate cattle against brucellosis; human illness is known to have resulted from RB51 vaccine–related exposures.1 The LPS is a voluntary proficiency-testing program developed jointly by the College of American Pathologists (CAP), Association of Public Health Laboratories (APHL), and CDC. The program is designed to exercise protocols for "rule-out" or "referral" of potential bioterrorism agents. During the October-November LPS exercise, 1,316 laboratories participated. Written LPS instructions instructed laboratories to handle and manipulate all samples under a Class II Biological Safety Cabinet (Class II BSC), using Biological Safety Level 3 (BSL3) primary barriers. The reported exposures occurred when an . . . [Full Text of this Article]
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