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The Multiple Risk Factor Intervention Trial (MRFIT)—Importance Then and Now
Commentary by Jeremiah Stamler, MD;
James D. Neaton, PhD
JAMA. 2008;300(11):1343-1345.
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SUMMARY OF THE ORIGINAL ARTICLE
Is Relationship Between Serum Cholesterol and Risk of Premature Death From Coronary Heart Disease Continuous and Graded? Findings in 356 222 Primary Screenees of the Multiple Risk Factor Intervention Trial (MRFIT)
Jeremiah Stamler, MD; Deborah Wentworth, MPH; James D. Neaton, PhD; for the MRFIT Research Group
JAMA. 1986;256(20):2823-2828
The 356 222 men aged 35 to 57 years, who were free of a history of hospitalization for myocardial infarction, screened by the Multiple Risk Factor Intervention Trial (MRFIT) in its recruitment effort, constitute the largest cohort with standardized serum cholesterol measurements and long-term mortality follow-up. For each five-year age group, the relationship between serum cholesterol and coronary heart disease (CHD) death rate was continuous, graded, and strong. For the entire group aged 35 to 57 years at entry, the age-adjusted risks of CHD death in cholesterol quintiles 2 through . . . [Full Text of this Article]
Data Regarding Other Cohorts
Author Affiliations: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (Dr Stamler); Department of Biostatistics, School of Public Health, University of Minnesota, Minneapolis (Dr Neaton).
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