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Tracy Hampton, PhD

JAMA. 2008;300(17):1989.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A search of cancer genes has uncovered a number of previously unknown mutations linked to the most common type of adult brain tumor that may help explain how the disease develops (The Cancer Genome Atlas Research Network. Nature. 10.1038/nature07385 [published online ahead of print September 4, 2008]).

Investigators within the Cancer Genome Atlas Research Network at 18 participating institutions and organizations published their interim analysis of DNA copy number, gene expression, and DNA methylation aberrations found in tumor samples from 206 patients with glioblastoma. They also reported nucleotide sequence aberrations in 91 of the 206 glioblastomas.

The analysis found roles for 3 genes—ERBB2 (known to be involved in breast cancer), NF1 (which causes neurofibromatosis), and TP53 (which encodes the tumor suppressor p53)—in glioblastoma. It also uncovered frequent mutations of the phosphatidylinositol-3-OH kinase regulatory subunit gene PIK3R1, and it revealed information on the pathways altered . . . [Full Text of this Article]

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