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Nosocomial Transmission of Human Granulocytic Anaplasmosis?
Peter J. Krause, MD;
Gary P. Wormser, MD
JAMA. 2008;300(19):2308-2309.
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In this issue of JAMA, Zhang and colleagues describe a possible nosocomial outbreak of human granulocytic anaplasmosis (HGA) in China.1 The clinical presentation of the index case, a previously healthy 50-year-old woman who developed a febrile illness with rash and massive bleeding and who died 5 days later, is consistent with many infectious etiologies including viral hemorrhagic fever (VHF) for which she was given ribavirin.2 Laboratory studies in 9 subsequent cases in family members and health care workers who had contact with the patient, however, suggested that her disease was HGA.
Human granulocytic anaplasmosis is an emerging tick-borne infectious disease caused by Anaplasma phagocytophilum that occurs in Lyme disease–endemic areas in the United States and sporadically in Europe. Clinical manifestations of HGA are usually mild to moderate and most patients promptly respond to treatment with doxycycline, which neither the index patient . . . [Full Text of this Article]
Author Affiliations: Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut (Dr Krause), and the Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York (Dr Wormser).
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