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Reactivation of Cytomegalovirus Infection in Critically Ill Immunocompetent Patients—Reply
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In Reply: In response to Dr Peppercorn and colleagues, one of the major goals of our study was to determine whether a broad range of causes of critical illness could induce CMV reactivation. Thus, we intentionally included patients from 4 ICUs (cardiac, trauma, burn, and medical) and demonstrated that CMV reactivation occurred in response to each of the insults (myocardial infarction, trauma, burn, or sepsis) associated with their respective ICUs. Despite differences in the incidence, timing, and duration of CMV reactivation by ICU, the finding that such diverse insults could all lead to CMV reactivation is a novel observation.
In the primary analysis that included all ICUs, we did not find an independent association between ICU type and risk of CMV reactivation in multivariable analysis adjusted for age, sex, and race (Table 3). There were significant differences in the primary composite end point (continued hospitalization or death by day 30) . . . [Full Text of this Article]
Ajit P. Limaye, MD
limaye@u.washington.edu
University of Washington
Seattle
Wendy M. Leisenring, ScD;
Michael Boeckh, MD
Fred Hutchinson Cancer Research Center
Seattle, Washington
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RELATED LETTER
Reactivation of Cytomegalovirus Infection in Critically Ill Immunocompetent Patients
Amanda Peppercorn, Jonathan Serody, and Bruce Cairns
JAMA. 2008;300(20):2367-2368.
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