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Edited by Dhavendra Kumar and David Weatherall
672 pp, $175.50
New York, NY, Oxford University Press, 2008
ISBN-13: 978-0-1951-8813-4

JAMA. 2008;300(20):2430-2431.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Geneticists say that "Everything is genetic, except maybe trauma." Genomics and Clinical Medicine confirms this axiom and notes that the body's response to physical injury also has genetic underpinnings. Arguably, however, the saying should be updated to state that "Everything is genomic, except maybe trauma." The difference is more than mere definition. "Genetics" focuses on single genes and their effects, whereas "genomics" refers to the action of all of the genes in an organism. Genomics also refers to a set of associated technologies (eg, high-throughput sequencing, expression profiling with microarrays). Genomics, in both senses, was largely born of the Human Genome Project—the effort to sequence the human genome.

Genomics and Clinical Medicine is the first textbook to comprehensively examine medicine, especially patho-physiology and pathogenesis, through the lens of genomics. The first 9 chapters, which comprise the "General Genomics" section, present a thorough introduction to the concepts as well as philosophy . . . [Full Text of this Article]

Douglas R. Stewart, MD, Reviewer
National Human Genome Research Institute
National Institutes of Health
Bethesda, Maryland
drstewart@mail.nih.gov

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