This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (2)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Topic Collections  • Diet  • Drug Therapy  • Adverse Effects  • Alert me on articles by topic  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: Recent literature has associated potential adverse effects with daily use of folic acid supplements (1000 µg),¹ high concentrations of serum folate (26.5 ng/mL or greater [to convert to nmol/L, multiply by 2.266]),² or high folic acid intake,³ but researchers have not adequately considered the source of folic acid. We examined the relative contribution of different sources of folic acid to serum folate concentrations among US adults.

Methods

Data were obtained from a single 24-hour dietary recall from the National Health and Nutrition Examination Survey (NHANES) 2001 through 2004 for 8655 nonpregnant participants aged 19 years and older who also had serum folate concentrations measured. The 24-hour dietary recall in NHANES underestimates energy intake by 11% among adults.⁴ Daily folic acid intake from individual fortified foods was calculated.⁵ Average daily intake of folic acid from supplements over the prior 30 days was calculated.⁶ The 3 main sources of dietary . . . [Full Text of this Article]

Lorraine Yeung, MD, MPH
Division of Birth Defects and Developmental Disabilities
National Center on Birth Defects and Developmental Disabilities

Quanhe Yang, PhD
National Office of Public Health Genomics

R. J. Berry, MD, MPHTM
rjberry@cdc.gov
Division of Birth Defects and Developmental Disabilities
National Center on Birth Defects and Developmental Disabilities
Centers for Disease Control and Prevention
Atlanta, Georgia

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci
Lindzon et al.
Carcinogenesis 2009;30:1536-1543.
ABSTRACT | FULL TEXT