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Arsenic Exposure and Diabetes Mellitus in the United States
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To the Editor: Dr Navas-Acien and colleagues1 extended the observation of a diabetogenic effect of arsenic exposure from drinking water containing arsenic levels greater than 100 µg/L in Taiwan, Bangladesh, and Mexico to a fairly low exposure of approximately 0.1 µg/kg per day in the United States. This low exposure dosage is approximately 55 times lower than that observed in the arseniasis-endemic areas (assuming that a 55-kg adult drinks 3 L of water containing an arsenic level of 100 µg/L per day). The odds ratios comparing the 80th vs the 20th percentile of total urine levels of arsenic and the trend test for the tertile stratification were significant only in the models considering seafood intake (ie, with additional adjustment for arsenobetaine and blood mercury levels).
In addition to the limitations discussed by the authors, the study did not adjust for family history of diabetes, which is a strong risk factor . . . [Full Text of this Article]
Chin-Hsiao Tseng, MD, PhD
ccktsh@ms6.hinet.net
Department of Medical Research and Development
National Taiwan University Hospital Yun-Lin Branch
Yun-Lin, Taiwan
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