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Commentary by J. Erin Staples, MD, PhD; Thomas P. Monath, MD

JAMA. 2008;300(8):960-962.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

SUMMARY OF THE ORIGINAL ARTICLE

The Etiology of Yellow Fever: An Additional Note

Walter Reed, MD, Jas. Carroll, MD, and Aristides Agramonte, MD

JAMA. 1901;36:431-440

The article describes a series of experiments conducted to explore how yellow fever is propagated from individual to individual and how the contagium is spread within households. The study was conducted in an experimental sanitary station in Cuba, where exposures and movements could be completely controlled. During the investigation, 12 nonimmune persons underwent different exposures, including mosquitoes that had fed on yellow fever patients, blood from infected patients, and fomites belonging to infected patients.

The study provided the following observations: (1) Aedes aegypti mosquitoes transferred the disease from an infected individual to a nonimmune person; (2) at least 12 days were needed for the extrinsic incubation period in the mosquito before it could transmit . . . [Full Text of this Article]

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