Roentgenologic Examination of the Gallbladder (Cholecystography)The Article That Launched a New Era of Radiology
Commentary by Ronald G. Evens, MD
JAMA. 2009;301(1):100-101.
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SUMMARY OF THE ORIGINAL ARTICLE
Roentgenologic Examination of the Gallbladder: Preliminary Report of a New Method Utilizing the Intravenous Injection of Tetrabromphenolphthalein
Evarts A. Graham, MD, and Warren H. Cole, MD
JAMA. 1924;82(1):613-614
Organic phenolphthalein compounds had previously been injected intravenously into rabbits and dogs and observed to be concentrated into bile fluid. Graham and Cole identified a compound (the calcium salt of tetrabromphenolphthalein) that when given intravenously to patients resulted in "definite and cleanly cut shadows of the gallbladder" in radiographs of the abdomen obtained a few hours later.
Their preliminary results suggested that a normal gallbladder is usually visualized, while a pathologic gallbladder is more difficult to observe, and predicted an important diagnostic role for this new roentgenologic examination.
See PDF for full text of the original JAMA article.
Commentary
In 1924, Graham and Cole published a classic JAMA article1 with . . . [Full Text of this Article]
Author Affiliation: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri.
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