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In Reply: We agree with Dr Oba about the uncertainty regarding published articles about tiotropium. The study by Brusasco et al (reference 24 in our article) and Casaburi et al (2002) (reference 19) reported trial findings that had already been published, but without clearly acknowledging the respective earlier publications (Donahue et al [reference 25] and Casaburi et al (2000) [reference 23]), thus apparently representing duplicate publication. We have updated our analyses excluding the earlier data, and also have corrected a data extraction error from the study by Chan et al (reference 22). The complete revised results appear as a Correction in this issue of JAMA (see p 1227-1230), but the corrected estimates do not change the direction, magnitude, or statistical significance of the relative risk (RR) estimates for the primary outcome of myocardial infarction, stroke, and cardiovascular death (RR, 1.60; 95% confidence interval [CI], 1.22-2.10; P < .001); the individual end . . . [Full Text of this Article]

Sonal Singh, MD, MPH
sosingh@wfubmc.edu
Department of Medicine
School of Medicine
Wake Forest University
Winston Salem, North Carolina

Yoon K. Loke, MBBS, MD
School of Medicine, Health Policy and Practice
University of East Anglia
Norwich, England

Curt D. Furberg, MD, PhD
Division of Public Health Sciences
School of Medicine
Wake Forest University
Winston Salem, North Carolina

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