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To the Editor: In their systematic review and meta-analysis, Dr Whincup and colleagues¹ examined the association of birth weight and type 2 diabetes in adults. They found that in most of the middle-aged and older populations studied in their review, there were inverse, graded, and independent associations between birth weight and risk of type 2 diabetes. These associations were not dependent on adjustment for current body size nor confounded by adult socioeconomic status, although in most of the studies this association has been attributed to a programmed response to intrauterine malnutrition.

However, it is not known whether this association is explained by unfavorable intrauterine environment or by specific susceptibility genotypes predisposing to reduced insulin-mediated fetal growth, which could lead to altered insulin secretion or to insulin resistance with subsequent type 2 diabetes. Type 2 diabetes has a multifactorial etiology, with important contributions from obesity, lifestyle, and genetic factors that induce . . . [Full Text of this Article]

Mario J. A. Saad, MD; José B. C. Carvalheira, MD; Lício A. Velloso, MD
lavelloso@fcm.unicamp.br
Department of Internal Medicine
Faculty of Medical Sciences
University of Campinas
Campinas, Brazil

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Birth Weight and Risk of Type 2 Diabetes: A Systematic Review
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