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To the Editor: The Selenium and Vitamin E Cancer Prevention Trial (SELECT) by Dr Lippman and colleagues¹ reported that selenium or vitamin E alone or in combination did not prevent prostate cancer. The negative results of this trial confirm the outcomes in the Nutritional Prevention of Cancer (NPC) Trial for those participants with the highest baseline plasma selenium concentration prior to supplementation with selenized yeast.² The conclusion from both NPC and SELECT should be that daily selenium supplementation will not benefit all persons. Cancer risk reduction with selenium should be expected only in men with low or suboptimal levels prior to supplementation.

A U-shaped dose-response relationship between selenium intake and cancer risk, as suggested by studies in dogs,³ is consistent with the results of SELECT and NPC. At baseline, the average participant in SELECT had selenium status within the trough of the U-shaped curve, ie, not low or suboptimal. After . . . [Full Text of this Article]

Margaret P. Rayman, DPhil
m.rayman@surrey.ac.uk
Faculty of Health and Medical Sciences
University of Surrey
Guildford, United Kingdom

Gerald F. Combs Jr, PhD
Grand Forks Human Nutrition Research Center
Agricultural Research Service
US Department of Agriculture
Grand Forks, North Dakota

David J. Waters, PhD, DVM
Purdue University Center on Aging and the Life Course
West Lafayette, Indiana

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RELATED ARTICLE

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Scott M. Lippman, Eric A. Klein, Phyllis J. Goodman, M. Scott Lucia, Ian M. Thompson, Leslie G. Ford, Howard L. Parnes, Lori M. Minasian, J. Michael Gaziano, Jo Ann Hartline, J. Kellogg Parsons, James D. Bearden, III, E. David Crawford, Gary E. Goodman, Jaime Claudio, Eric Winquist, Elise D. Cook, Daniel D. Karp, Philip Walther, Michael M. Lieber, Alan R. Kristal, Amy K. Darke, Kathryn B. Arnold, Patricia A. Ganz, Regina M. Santella, Demetrius Albanes, Philip R. Taylor, Jeffrey L. Probstfield, T. J. Jagpal, John J. Crowley, Frank L. Meyskens, Jr, Laurence H. Baker, and Charles A. Coltman, Jr
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Selenium and Vitamin E Supplementation for Cancer Prevention
Rachel Hurst and Susan Fairweather-Tait
JAMA. 2009;301(18):1876-1877.
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Selenium and Vitamin E Supplementation for Cancer Prevention—Reply
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