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Rebecca Voelker

JAMA. 2009;301(2):147-149.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Chicago—In 1891, when Hans Chiari, MD, published his first account of abnormalities in the brain at the craniocervical junction, the Austrian pathologist could hardly have imagined the questions his work eventually would raise.

This image of the brain shows a Chiari I malformation, with displacement of the cerebellar tonsils below the level of the foramen magnum (arrowhead). (Photo credit: Konstantin Slavin, MD/University of Illinois at Chicago)

Chiari discovered these anomalies while performing postmortem examinations on children and adolescents with cerebral hydrocephalus. He described the irregularities as "cone-shaped projections" of the cerebellum that protruded below the foramen magnum and into the spinal canal (Bejjani GK. Neurosurg Focus. 2001;11[1]:1-8). Chiari recognized that the degree of these structural defects in the brain was not related to the severity of the hydrocephalus. But he offered no wholesale explanation for their cause, leaving physicians and scientists puzzled for more than a . . . [Full Text of this Article]

ADVANCING RESEARCH AND CARE



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