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Leukemia is a cancer of the white blood cells that spreads throughout the bloodstream and may affect many organs. It originates in the bone marrow (spongy center of bones), which is where all blood cells are developed before being released into the bloodstream. Leukemia is classified based on the type of abnormal white blood cell and by how rapidly these cells leave the bone marrow and enter the bloodstream. Acute myeloid leukemia (AML) is the most common type of leukemia that affects adults. The June 10, 2009, issue of JAMA contains an article on allogeneic (from a healthy donor other than an identical twin) stem cell transplantation as a treatment for AML.

SIGNS AND SYMPTOMS

• Excessive fatigue
  
• Fevers with night sweats
  
• Recurrent infections
  
• Swollen or bleeding gums
  
• Loss of appetite
  
• Enlarged liver or spleen
  
• Easy bruising
  
• Bone or joint pain
  

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RELATED ARTICLE

Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in First Complete Remission: Systematic Review and Meta-analysis of Prospective Clinical Trials
John Koreth, Richard Schlenk, Kenneth J. Kopecky, Sumihisa Honda, Jorge Sierra, Benjamin J. Djulbegovic, Martha Wadleigh, Daniel J. DeAngelo, Richard M. Stone, Hisashi Sakamaki, Frederick R. Appelbaum, Hartmut Döhner, Joseph H. Antin, Robert J. Soiffer, and Corey Cutler
JAMA. 2009;301(22):2349-2361.
ABSTRACT | FULL TEXT