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Allopurinol and the Role of Uric Acid in Hypertension—Reply
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In Reply: The purpose of our study was to investigate the role of uric acid in the pathogenesis of essential hypertension. As described in the article, it was predicated on numerous studies showing that an elevated uric acid level predicts the development of hypertension in the general population, the presence of hyperuricemia in 90% of adolescents with newly diagnosed essential hypertension, and the finding that raising uric acid causes hypertension in animals. Our short-term study resulted in normal blood pressure in 86% of hypertensive participants when their uric acid level was lowered to less than 5.0 mg/dL vs 3% when they received placebo treatment. (To convert uric acid to µmol/L, multiply by 59.485.)
The selection of allopurinol as the drug to lower uric acid was based on its efficacy, simplicity of administration, a well-established adverse effect profile that we could monitor, and a lack of better alternatives. The purpose of . . . [Full Text of this Article]
Daniel I. Feig, MD, PhD
dfeig@bcm.tmc.edu
Department of Pediatrics
Baylor College of Medicine
Houston, Texas
Richard J. Johnson, MD
Department of Medicine
University of Florida School of Medicine
Gainesville
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