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Acute Lymphoblastic Leukemia
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Acute lymphoblastic leukemia (ALL) is the most common cancer in children and represents about one-quarter of all cancers among persons younger than 15 years. Acute lymphoblastic leukemia is a cancer of the blood and bone marrow (spongy tissue in the center of bone). In ALL, too many bone marrow stem cells develop into a type of white blood cell called lymphocytes. These abnormal lymphocytes are not able to fight infection very well. Also, as the number of these lymphocytes increases, there is less room for healthy white blood cells, red blood cells, and platelets. This may lead to infection, fatigue, and easy bleeding. The January 28, 2009, issue of JAMA includes an article about genetic variations associated with treatment response in childhood ALL. This Patient Page is based on one previously published in the March 21, 2007, issue of JAMA.
LEUKEMIA SYMPTOMS
- Fatigue
- Fever
- Easy bruising
- Bone pain
DIAGNOSTIC TESTS
Janet M. Torpy, MD, Writer;
Cassio Lynm, MA, Illustrator;
Richard M. Glass, MD, Editor
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RELATED ARTICLE
Genome-wide Interrogation of Germline Genetic Variation Associated With Treatment Response in Childhood Acute Lymphoblastic Leukemia
Jun J. Yang, Cheng Cheng, Wenjian Yang, Deqing Pei, Xueyuan Cao, Yiping Fan, Stanley B. Pounds, Geoffrey Neale, Lisa R. Treviño, Deborah French, Dario Campana, James R. Downing, William E. Evans, Ching-Hon Pui, Meenakshi Devidas, W. P. Bowman, Bruce M. Camitta, Cheryl L. Willman, Stella M. Davies, Michael J. Borowitz, William L. Carroll, Stephen P. Hunger, and Mary V. Relling
JAMA. 2009;301(4):393-403.
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