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To the Editor: From a cross-sectional analysis of urinary chemical concentrations and health status in the general US adult population, Dr Lang and colleagues¹ reported that BPA was associated with cardiovascular diagnoses, diabetes, and abnormal liver enzyme concentrations. However, the potential for false positives, briefly mentioned but not analyzed, is substantial when the complete Centers for Disease Control and Prevention (CDC) design is examined.

The CDC NHANES (2003-2004)^2-3 measured 275 environmental chemicals and a wide range of health outcomes. Although the study by Lang et al focused on 1 chemical and 16 health outcomes (8 patient-reported medical outcomes and 8 clinical chemistry measurements), counting to determine how many questions were at issue and in how many ways these questions can be statistically analyzed is important.

Focusing only on the health outcomes selected by the authors, the analysis forms a 16 x 275 composite set of questions. However, there are more . . . [Full Text of this Article]

S. Stanley Young, PhD
young@niss.org
National Institute for Statistical Sciences
Research Triangle Park, North Carolina

Min Yu, MSc
University of British Columbia
Vancouver, British Columbia, Canada

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