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In Reply: Dr Wei and Ms Howard and Dr Howard comment on the observed association between BPA and diabetes in our study. Respondents to the NHANES 2003-2004 were asked, "Other than during pregnancy, have you ever been told by a doctor or health professional that you have diabetes or sugar diabetes?" Our analyses included 124 respondents replying yes plus 12 recorded as borderline. In fully adjusted models, geometric mean concentration of urinary BPA in the no group was 2.45 ng/mL (95% confidence interval [CI], 2.26-2.65 ng/mL); in the small borderline group, 5.97 ng/mL (95% CI, 4.01-8.88 ng/mL); and in the yes group, 2.86 ng/mL (95% CI, 2.42-3.37 ng/mL). Excluding the borderline response attenuated outcomes slightly in fully adjusted models: the odds ratio (OR) for responding yes vs no was 1.19 (95% CI, 1.00-1.41; P = .05) per 1-SD increase in BPA concentration. This equated to an OR of 2.38 (95% CI, . . . [Full Text of this Article]

David Melzer, MB, PhD
david.melzer@pms.ac.uk

Iain A. Lang, PhD
Epidemiology and Public Health Group
Peninsula Medical School
Exeter, United Kingdom

Tamara S. Galloway, PhD
School of Biosciences
University of Exeter
Exeter

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