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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In Reply: While we understand that there may be some ambiguity in the isolated sentence quoted by Dr Ponce-de-Leon, we do not believe that the context of the full abstract results section suggests a direct comparison between exposed and unexposed cohort members. The second sentence states, "Two hundred eighty-four patients (0.3%) had an adverse event," noting the overall adverse event rate in the entire cohort of men undergoing cataract surgery. The sentence describing the 7.5% and 2.7% adverse event rates was intended to refer to the proportions in the 280 cases and 1102 randomly matched controls. Moreover, the findings were reinforced by the final sentence that noted an estimated number needed to harm of 255, a statistic that incorporates absolute risk.¹

We agree with Dr Gaynes that identifying a theoretical cause and biological plausibility for our findings can be difficult. A disconnection between what would be expected from pharmacologic experiments . . . [Full Text of this Article]

Chaim Bell, MD, PhD
bellc@smh.toronto.on.ca
Department of Medicine
St Michael's Hospital
Toronto, Ontario, Canada

Andrea Gruneir, PhD; Paula Rochon, MD, MPH
Women's College Research Institute
Toronto

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